FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

The function of mast cells in angioneogenesis is not completely known. Their role in the processes of the stimulation, inhibition and regulation of the angiogenesis is connected with mediators of angiogenesis produced by mast cells, e.g. heparin, histamin, bFGF, VEGF, chymase, tryptase and hydrolases. The enzymatical actions of mast cells on extracellular matrix, mostly by proteases, change its structure and facilitate creation of three-dimensional vascular system. In this paper the literature data was discussed, proving direct and indirect role of mastocytes in neovascularization processes in malignant tumor. The interactions of the cells of extracellular matrix, mostly endothelial cells, mastocytes and fibroblasts, and role of mastocytes in metabolic regulation of angioneogenesis were described. The methods of studies on mast cells and angiogenesis were presented.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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