FIND ARTICLE

Volume: 
Issue: 
4
Date of issue: 

Ageing and diseases connected with ageing currently became very important social problem. Ageing processes can be faster because of accumulation of toxic metabolic products. This substances could be products of non enzymatic glycosylation (glycation). Glycation may there fore play an impor- tant role in ageing and has been implicated in the pathophysiology of a number of diseases, like: Alzheimer disease, arteriosclerosis, diabetes, kidney diseases, blood circulation system diseases and lung diseases. Products of non-enzymatic glycosylation of proteins are formed in chemical reaction between reducing sugar, frequently glucose molecule and free amino groups located either at the N-terminal end of the polypeptide chains or on the lysine side chains. They are long-living molecules which can form cross- linking between proteins and extracellular matrix.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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