FIND ARTICLE

Volume: 
Issue: 
1
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Hepatic stellate cells (synonyms : lipocytes , perisinusoidalne liver cells , the cells accumulate lipids, Ito cells ) are located in the perisinusoidal space ( of Disse ) , and their basic morphological feature is the presence of numerous lipid vacuoles ( covering approximately 20% of the cell volume ) and long spike entangling often hepatic sinus wall . Under normal conditions , stellate cells comprise 70-80 % of the vitamin A in the body plays a key role in the metabolism of the compound. Most stellate cells produce extracellular matrix components płacika liver , and enzymes involved in the degradation. Due to the presence ( -actin of smooth myocytes , and the presence of receptors for a number of vasoactive substances , stellate cells shrink and modulate blood flow in the liver sinuses . Cultured HSC spontaneously converted referred to as activation by which there is loss of lipid vacuoles , proliferation and migration of these cells and the secretion of various extracellular matrix components , and a number of other compounds , such as cytokines, growth factors and vasoactive substances . END hepatocytes leads to the transformation of stellate cells of metabolically active cells myofibroblast phenotype which play a crucial role in the development liver fibrosis .

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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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