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Recently, TRIM (tripartite motif-containing) proteins attrackted much attention. These receptors constitute a large family of proteins involved in an innate immunity and in a broad range of biological processes. Their universality is conditioned by their diversity, differences in tissue expression and cell localization. TRIMs have been classified into 9 families C-I to C-IX, and additionally C-X and CXI have been described recently. Numbers of TRIMPs vary in different animal species. The most commonly described role of these receptors is their engagement in retroviral infections, for example HIV, MLV or ALV. Many of TRIMs are IFN-induced what makes them important in pathogen immunity. Moreover, TRIMs are engaged in regulation of signaling pathways induced by TLRs and RIG-I.
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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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