FIND ARTICLE

Volume: 
Issue: 
4
Date of issue: 

Developing vertebrate limb is a model system frequently used to study tissue differentiation and patterning. Research methods based on sophisticated genetic and molecular embryology techni- ques allowed revising some of the longstanding hypotheses in this field of research. One of them proposed the mechanism of limb development along proximal-distal axis based on the existence of Progress Zone. Recent results propose an alternative model of limb differentiation along this axis, so called Predetermination Model. Additionally, an unexpected function of sonic hedgehog in the determi- nation of digit number and identity was recently proposed. Some of those findings will be discussed in this article.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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