FIND ARTICLE

Volume: 
Issue: 
4
Date of issue: 

A development of contemporary methods of therapy as gene therapy is directly based on a search of genes that encode therapeutic proteins. Angiogenic gene therapy takes advantage of genes encoding proangio- genic factors. It is described that embryonic sonic hedgehog protein is a strong stimulator of neovascularization. Sonic hedgehog is implicated in the regulation of central nervous system polarity and differentiation of various organs. Recent findings indicate that sonic hedgehog based gene therapy accelerates wound healing by enhancing endothelial progenitor cell-mediated microvascular remodeling. It is also known that SHH induces arteriogene- sis. Further studies of complex SHH signaling pathway will reveal whether proangiogenic potency of sonic hedgehog protein determine the progress of cardiovascular gene therapy.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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