FIND ARTICLE

Volume: 
Issue: 
4
Date of issue: 

Gal-3 shares several significant structural properties with Bcl-2 family. Both proteins contain anti-death motif, critical for their anti-apoptotic function but the mechanism by which gal-3 exhibits antiapoptotic activity cannot be explained solely on it. Depending on the type, state and condition of the cell as well as depending on the type of stimulus gal-3 can show pro- or anti-apoptotic activity. Cytoplasmic gal-3 expression seems to be strongly implicated in an anti-apoptotic function and drug resistance in cancer cells, suggesting that cytoplasmic gal-3 is a candidate target protein to suppress anticancer drug resistance. Gal-3 previously known as IgE-binding protein is a pro-inflammatory lectin. In response to pro-inflammatory agents some cells produce and release high amount of gal-3. Taking together, gal-3 can provide a new therapeutic target for improving chemotherapy of cancer. In addition the detection of extracellular gal-3 may be of diagnostic value as prognostic cancer marker.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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