Central nervous system is in unique manner isolated from the direct influence of external environment. This isolation is possible thanks to the existence of complicated in its structure, blood-brain barrier, which is a compilation of anatomical as well as physiological attributes. It is characteristic that connections between endothelial cells are tightening, which is an obvious passive transport obstacle and active carriage through the barrier dominates. Disruption of barrier continuity can happen due to many neurological diseases, but undoubtedly, the main reasons are brain injuries, which may increasingly be growing medical problem. Therefore, so important are every type of studies on structure and permeability of blood-brain barrier because they provide more and more detailed data, which broaden our knowledge.