The physiological role of tyreoliberyny ( TRH ) is to maintain homeostasis within the four systems: ( i) the neuroendocrine hypothalamus -pituitary gland, (ii ) neuronal pathway brainstem - midbrain - spinal cord, ( iii ) the limbic - cortical and (iv ) the chronobiologic. In this way, TRH through different cellular mechanisms regulate many biological processes ( general stimulation of the body , sleep , learning, lokomotorykę mood ) and can be considered for intervention and clinical use in the event of disturbance in the individual systems . Because of the adverse pharmacological profile TRH ( enzymatic instability , short duration of action , side effects ) , created a number of synthetic analogues to its potential use as monotherapy or adjunctive therapy in many diseases of the central nervous system ( CNS). This paper presents the current state of knowledge on the physiological action of TRH, its potential benefits in the treatment of CNS disorders including the study of its analogues.