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The physiological role of tyreoliberyny ( TRH ) is to maintain homeostasis within the four systems: ( i) the neuroendocrine hypothalamus -pituitary gland, (ii ) neuronal pathway brainstem - midbrain - spinal cord, ( iii ) the limbic - cortical and (iv ) the chronobiologic. In this way, TRH through different cellular mechanisms regulate many biological processes ( general stimulation of the body , sleep , learning, lokomotorykę mood ) and can be considered for intervention and clinical use in the event of disturbance in the individual systems . Because of the adverse pharmacological profile TRH ( enzymatic instability , short duration of action , side effects ) , created a number of synthetic analogues to its potential use as monotherapy or adjunctive therapy in many diseases of the central nervous system ( CNS). This paper presents the current state of knowledge on the physiological action of TRH, its potential benefits in the treatment of CNS disorders including the study of its analogues.

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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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