Gal-3 shares several significant structural properties with Bcl-2 family. Both proteins contain anti-death motif, critical for their anti-apoptotic function but the mechanism by which gal-3 exhibits antiapoptotic activity cannot be explained solely on it. Depending on the type, state and condition of the cell as well as depending on the type of stimulus gal-3 can show pro- or anti-apoptotic activity.

Endothelial cells play a critical role in blood circulation and hemostasis, in arteriosclerosis, inflamation and cancer progression. Low cellular turnover, and migration and proliferation capacity in response to specific stimuli are characteristic features of endothelial cells. High endothelial venules in lymph nodes are the type of endothelium specialised in lymphocyte circulation. E selectin and other endothelium specific adhesive molecules called addressins, initiate process of leukocytes' adhesion to the vascular wall.