FIND ARTICLE

MECHANISMS OF a-AMANITIN HEPATOTOXICITY AND COMPARATIVE ANTIDOTAL EFFICACY OF SUBSTANCES USED IN AMANITA PHALLOIDES INTOXICATION A REVIEW OF EXPERIMENTS ON PRIMARY HEPATOCYTE CULTURES

The course of a-amanitin (a-AMA) toxicity in cultured canine and human hepatocytes is divided into 2 phases. The first phase comprises mainly functional cell impairments expressed by inhibition of protein and urea synthesis. The second stage is lethal and is characterized by ongoing necrosis and/ or apoptosis. a-AMA-induced apoptosis in human heptocyte cultures is p53- and caspase-3-dependent. Moreover, a-AMA causes increase in SOD activity, reduction of CAT activity and a significant increase in lipid peroxidation in cells, which may contribute to its severe hepatotoxicity.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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