Regulatory proteins SOCS 1-7 (suppressors of cytokine signaling), CIS (cytokine-inducible SH 2 protein) and other intracellular molecules such as JAKs (Janus tyrosine kinases), STATs family (signal transducers and activators of transcription), which participate in immunological response, could influence differentiation and proliferation, cell apoptosis, cell-cycle progression, cytokines and growth factors secretion by regulation of proper genes which determine these process in neoplasm cells and blood cells.

STAT mediators comprise a family of seven proteins, that play a key role in intracellular signaling. They are involved in cell differentiation, proliferation and cell death. This article presents a description of STAT proteins with a focus on their probable role in pathology of alimentary system, particularly inflammatory bowel disease and colon carcinogenesis. In inflammatory bowel disease action of STAT3, STAT1, STAT 4 predominates. STAT1 and STAT3 play remarkable roles in colon carcinoma. It was discovered that STAT1 blocks cell proliferation in cell lines of colorectal cancer.