Discovered in 1897, aspirin (acetylsalicylic acid) was the most important and most widely used anti-inflammatory drug , analgesic and przeciwgoršczkowym in the twentieth century. Aspirin and its analogues called a common nonsteroidal antiinflammatory drugs ( NSAIDs) through a common mechanism działajš based on the ability to inhibit the enzyme cyclooxygenase . Cyclooxygenase istniejš in at least two varieties: constitutive (COX -1) and inducible (COX -2). Aspirin and other NSAIDs inhibit both isoforms invol COX .