Doxorubicin and paclitaxel cause different changes in the fluidity of the plasma membrane of breast cancer cells MCF-7

Was studied by fluorescence spectroscopy methods of anticancer drugs doxorubicin interaction (DOX ) and paclitaxel ( PTX ) on the properties of the plasma membrane of cells of MCF- 7 breast adenocarcinoma . Used fluorescent probes TMA- DPH and Daud , allow the determination of external liquidity , the polar regions and the hydrophobic core of the lipid bilayer . It was found varying effects of both drugs . DOX and PTX influenced differently at the surface and the hydrophobic region of the membrane. Similar and DOX induced concentration-dependent changes in both areas of the lipid bilayer .

The role of the peptides in the selective delivery of anthracyclines for cancer cells

Doxorubicin (DOX ) and other anthracyclines are commonly used in the treatment of cancer, both leukemias and solid tumors. The clinical use of these drugs is limited by side effects , especially the cardiotoxicity , myelosuppression , or damage to the kidneys . Efforts are therefore numerous studies aimed at reducing the side effects and increase the efficacy of doxorubicin and other anthracyclines . One alternative strategy is the use of drugs conveyors , such as liposomes, dendrimers , or the antibody nanoparticles .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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