Dental enamel is the most mineralized tissue all over the body. The enamel development begins with the organic matrix secretion. The enamel extracellular matrix mainly consists of amelogenins and enamelins. As the enamel maturation progress the organic matrix undergoes proteolitic degradation. The remnants, which remain after the degradation are subsequently withdrawn and replaced with hydro- xyapatites crystals which form the enamel prisms. The enamel secretion and maturation can be modified by fluoride ions supplemented per os.