For many years mitochondria have been implicated in the process of carcinogenesis. At the beginning of 20th century Otto Warburg has started research focused on failure of oxadative metabolism in cancer cells. In his work he described disruption of respiration as typical for cancer cells. Warburgs discovery resulted in establishment of many projects focused on the role of mitochondria in cell transformation. Since that time multiple reasearch groups have reported mitochondria DNA mutations in majority types of cancer.