Innate immunity is the first and in most organisms sole line of defence against pathogenic microorganisms. The activity of mechanisms of innate immunity starts with recognition of pathogen- associated molecular pattern (PAMP) by proteins that contain leucine rich repeats (LRR) domain. Plant proteins ‘R’ contain TIR, NBD and LRR domains and recognize specifically fungal, bacterial or viral pathogens. After pathogen detection signal cascade is initiated that results in most cases with hypersen- sitive reaction in region of infection.