Endothelial Progenitor Cells: origin, characteristics and prospects of use in therapy

Vascular endothelium and the blood cells are derived from mesodermal cells of the common hemangioblastu. The confirmation of the close relationship of both cell lines are common antigens, occurring in the early stages of differentiation. Endothelial precursor cells, defined as CD34 + CD133 + Flk-1 +, can be differentiated in vitro cultured endothelial cells. Progenitors of endothelial cells, isolated from bone marrow, cord blood and peripheral blood in vivo may incorporate into the vessel wall and damaged endothelial function to take.

Genetic instability in cancer. I. Chromosomal Instability in Cancer

Genetic instability, chromosomal or / and microsatellite is one of the characteristics of tumor cells. In tumor cells, both solid tumors and hematologic malignancies chromosomal instability expressed by the accumulation of structural and numerical aberrations of chromosomes. Chromosomal aberrations in tumors may be changes in specific, critical for the transition process, or secondary, which are the expression and at the same time cause genetic instability of cancer cells.

ALCAM/CD166 (Activated Leukocyte Cell Adhesion Molecule) - adhesion molecule regulates growth, development, aggregation and migration of healthy and cancerous cells

ALCAM ( Activated Leukocyte Cell Adhesion Molecule ) / CD166 is a member of a small sub-group of transmembrane glycoproteins belonging to the immunoglobulin superfamily . The fully formed protein assigned to this group are characterized by the presence of three fragments : the extracellular międzybłonowego and a short cytoplasmic region . ALCAM/CD166 participates in heterophile ( ALCAM/CD166-CD6 ) and homofilnej ( ALCAM/CD166-ALCAM/CD166 ) in a variety of cell adhesion tissues and cell lines .

The variability of ferritin in pathological

Ferritin plays an important role in all living organisms, keeping the iron in the form of accessible and harmless. Its synthesis is tightly regulated both at the transcriptional and translational, and its expression is influenced by many factors. Maintaining the proper level of this protein is essential for the functioning of the body and is a kind of indicator of health.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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