FIND ARTICLE

INDUCED PLURIPOTENT STEM CELLS HOPES, FEARS AND VISIONS

In 2006 first paper describing reprogramming of fibroblast into pluripotent cell, i.e. one that is able to differentiate into all tissues was published. Before that spectacular achievement many projects devoted to study the mechanisms of cell de-differentiation led to the establishment of animal cloning techniques and also derivation of embryonic stem cell lines. Present review summarizes the history of these studies and also describes pioneer works leading to derivation of induced pluripotent stem cells, current methods of reprogramming, and possible applications of these cells.

EMBRYONIC STEM CELLS - SEARCHING FOR THE PLURIPOTENCY

In 2007, the Nobel Prize in Physiology and Medicine was awarded to Martin Evans, Mario Cappecchiemu and Olivier Smithiesowi. Martin Evans has been honored for the isolation of pluripotent mouse embryonic stem cells (ES cells), two other researchers for developing methods of genetic modification of these komórek.Tutaj presents the history of obtaining embryonic stem cells, methods of inducing their differentiation targeted in vivo and in vitro, as well as selected issues associated with the potential use of these cells for therapy.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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