Recently, TRIM (tripartite motif-containing) proteins attrackted much attention. These receptors constitute a large family of proteins involved in an innate immunity and in a broad range of biological processes. Their universality is conditioned by their diversity, differences in tissue expression and cell localization. TRIMs have been classified into 9 families C-I to C-IX, and additionally C-X and CXI have been described recently. Numbers of TRIMPs vary in different animal species.

Ageing and diseases connected with ageing currently became very important social problem. Ageing processes can be faster because of accumulation of toxic metabolic products. This substances could be products of non enzymatic glycosylation (glycation). Glycation may there fore play an impor- tant role in ageing and has been implicated in the pathophysiology of a number of diseases, like: Alzheimer disease, arteriosclerosis, diabetes, kidney diseases, blood circulation system diseases and lung diseases.