Toll-like receptors (TLRs), TNF receptor (TNF-R), NF-κB and the nuclear factor NF-κB family could influence cell-cycle progression, cell apoptosis, cytokines and adhesion molecules by regu- lation of proper genes which determine these process in neoplasm cells and blood cells. The aim of this study was to introduce the latest knowledge of the nuclear factor NF-κB family role in oncogenesis and neoplasm progression.