FIND ARTICLE

Volume: 
Issue: 
1
Date of issue: 

The trefoil family of peptides is mainly associated with gastrointestinal tract. These peptides protect the mucous layer. The protective role of trefoil peptides is explained by their interaction with carbohydrates attached to mucin glycoproteins and by maintenance of the mucus structure. Trefoil peptides influence migration of epithelial cells and thus contribute to regeneration of the mucous layer. A correlation between trefoil peptides and oncogenesis remains unclear. In the gastrointestinal tract, trefoil peptides are considered to be one of more important factors protecting them against cancer. However, in lobular breast cancer, trefoil peptides may facilitate the tumor development. Possibly, a migration of neoplastic cells, influenced by trefoil peptides is responsible for metastases and tumor progression.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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