FIND ARTICLE

Volume: 
Issue: 
1
Date of issue: 

Proteoglycans, produced by most eukaryotic cells are versatile components of pericellular and extracellular matrix. They are composed of protein core to which one or more glycosamino-glycan (GAG) chains are attached. One of few families of proteoglycans are glypicans. All glypicans share similar features as core protein of 60 kDa, 14 conserved cysteine residues, a special region localized near the plasma membrane, containing 2 or more Ser-Gly sequences for GAG attachment, hydrophobic C- and N-terminal parts of core protein similar to signal peptide, as well as linkage with external leaflet of the plasma membrane via a glycosylpho-sphatidylinositol. The glypicans are implicated in cell division, adhesion, migration and modulation of growth factor activities. Mutation in glypicans may cause few congenital diseases and premature death.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

PBK Postępby biologi komórki