FIND ARTICLE

APOPTOSIS – TARGETED ANTICANCER THERAPY

Apoptosis is the major form of cell suicide. Most conventional anticancer agents induce apoptosis indirectly. Although chemiotherapeutic drugs should selectively kill only tumor cells, normal cells are often susceptible to cytotoxic or cytostatic effects of these agents. This is a reason of potentially harmful side effects including inflammation and damage to the surrounding normal tissue.

Leukemic cell resistance mechanisms involving oncogenic tyrosine kinases

Philadelphia chromosome (Ph) is the result of a chromosomal translocation leads to malignant transformation of hematopoietic cells . The reason is oncogenic tyrosine kinase activity of the BCR / ABL fusion gene resulting from following the transfer of a fragment of chromosome 9 to chromosome 22 [ t ( 9 , 22 )] . There is a whole family of tyrosine kinases fusion ( FTKs ) related to BCR / ABL , such as the TEL / ABL , TEL/JAK2 , TEL / TRKC (L) , TEL / PDGFâR and NPM / ALK , which induce both acute and chronic myelogenous leukemias and lymphomas.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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