Vanadium derivatives as compounds of biological significance. Part II. Influence on tumor cells

Vanadium derivatives, besides the impact on growth, development and differentiation of certain species and antidiabetic properties, may also affect the cells and induce their apoptosis, proliferation or neoplastic transformation. This effect depends on the model of experience and its conditions. Compounds of vanadium can act as promująco inhibitory factors or pro-or anti-cancer, i.e. induce or inhibit growth and survival of neoplastic cell proliferation. They act on animal and human cells, affecting not only on tumor cells but also normal.

Kinetics and regulation of Smac / DIABLO release from the mitochondria of cancer cells upon stimulation Apoptogenic

Most of the currently used anticancer drugs and radiotherapy induces apoptosis by DNA damage or inhibition of key enzymes involved in cell survival signaling pathways . This triggers a cascade of reactions leading to the activation of pro-apoptotic proteins Bcl- 2 family , such as Bad , Bid , Bax or Bak , forming a specific channel or coformation of megachannels ( mPTP ) in the outer mitochondrial membrane , allow the release of apoptogenic proteins , such as cytochrome c , Smac / DIABLO , AIF , Omi/HtrA2 , procaspase 9 and 3 and endonuclease G.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
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