FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

Opioid peptides belong to a group of agents, produced in porcine ovarian follicles, which affect functions of granulosa and theca interna cells. During short incubation of the cells with opioids (µ δ or κ agonists) inhibition of steroidogenesis prevails, while in the presence of LH, trophic agent for these cells (from large follicles), stimulation of steroid hormones under influence of opioids predominates. The mechanism of inhibitory action of opioids on follicular steroidogenesis was investigated using the agonist of mainly µ receptors, FK 33-824. Under influence of FK 33-824 it was found attenuation of adenylyl cyclase, protein kinases A and C activities in granulosa cells as well as phosphoinositide-specific pho- spholipase C, adenylyl cyclase, protein kinases A and C activities in theca interna cells.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

PBK Postępby biologi komórki