FIND ARTICLE

PEPTIDERGIC MODULATION OF GONADOTROPIN SUBUNIT GENE EXPRESSION IN THE ANTERIOR PITUITARY OF FEMALE RATS

Transcription activity of genes encoding three gonadotropin subunits: (α, LHβ, FSHβ) de- pends on specific cis- and trans-acting regulatory elements located on their promoters. Gonadotropin releasing hormone (GnRH) is a crucial neurohormon stimulating these genes transcriptional activity. Pulsatile intracerebroventricular microinjections of GnRH, β-endorphin, vasoactive intestinal peptide (VIP) and galanin in ovariectomized rats revealed their significant role in the modulation of gonadotropin subunits gene expression.

Gonadotropin-dependent regulation of transcriptional activity of genes encoding subunits of luteinizing hormone in the pituitary gland

GnRH (GnRH) is a key regulator of the expression of specific genes encoding three gonadotropin subunits (?, LH? And FSHb) in the pituitary. The promoter of the gene protein LHb SF-​​1, EGR-1 and SP-1 to form a complex, three-part regulatory element responsible for full activation of transcription of the gene by GnRH. The position -443 promoter sequence identified CCATTTTTGG (called CArG box) responsible for gene activation by pulsed LHb released GnRH.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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