The reorganization of the structure and function of podocytes in idiopathic nephrotic syndromes in children

The cause of proteinuria in idiopathic nephrotic syndromes in children is increased permeability of the glomerular filtration barrier following the action of immune and non-immune . Podocytes , thanks to specific proteins of the cytoskeleton ( cytokeratin , vimentin , actin ) and particles stabilizing their intracellular organization (complex podokaliksyna - ezryna - On exchanger regulatory factor -H - actin , synaptopodin ) and proteins films fissured ( podocyn , nephrin ) are responsible for the proper filtration process in the glomerulus .


For several decades, it has been assumed that plasminogen activation may play an important role in tumor invasion and metastasis. The basic idea is that plasminogen activators released from cancer cells catalyze the proteolytic conversion of the inactive zymogen plasminogen to the active proteinase plasmin, which in turn catalyzes degradation of proteins in basement membranes and extracellular matrix (ECM) and thus facilitates cancer cell invasion into the surrounding tissue.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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