The skin is a complex organ of human body, which plays an essential role, providing physical barrier against mechanical, chemical and biological factors and, through its pigments produced in melanocytes, provides defense system against UV radiation, and reduces the risk of UV-induced DNA damage in human epidermis. The skin is composed of three layers: epidermis and its derivatives, dermis, and hypodermis. The function of the skin, especially hair growth and activity of sebaceous glands, is regulated by sex steroids, and skin is the target organ for these hormones.