FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

In mammalian cells the clathrin coated vesicles participate in receptor mediated internalization, transport and sorting of macromolecules from the trans Golgi network to the endocytic pathway as well as from the plasma membrane to endosomes and lysosomes. The complex protein machinery controlling vesicle budding, transport and fusion are significantly conserved between the endocytic and sorting pathways. The internalization and intracellular transport are based respectively on tyrosine (YXXĆ) and dileucine (LL) signals. The overall processes include: interaction between the ligand and the membrane receptor, association of the ligand-receptor complex with appropriate adaptor protein (AP-1, AP-2, AP-3, AP-4), coating with clathrin or clathrin-like proteins, budding of the vesicle, sorting and interaction with the target membrane. Advances in understanding the molecular mechanisms of the receptor mediated endocytosis and sorting processes, especially those connected with AP-1 i AP-2 adaptor complexes are described in this paper.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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