FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

E - NTPDases ( Ecto - Nucleoside Triphosphate Diphosphohydrolase family , E - phosphohydrolase ATP) , previously called ecto- ATPases and ecto- apirazami , are enzymes which, in the presence of millimolar concentrations of extracellular divalent cations hydrolyze the tri- and diphosphonucleosides . Much evidence indicates that the E - NTPDases are involved in the transmission of information with ATP and P2 purynoreceptorów . The E phosphohydrolases ATP - neurotransmission is not limited to the removal of P2 receptor agonists . These enzymes by maintaining a balance between the concentration of ATP and adenosine also regulate the speed and intensity of the response of cells to purinergic signal . Lack of [ ATP] : [E -adenosine ] can lead to many serious diseases . So far it is not clear sense of occurrence in areas of synaptic E - NTPDases 2 In our opinion , this enzyme is involved in lowering high ATP concentrations in the synapse , and the creation of another neurotransmitter ATP - ADP .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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