FIND ARTICLE

MOLECULAR OSCILLATORY CLOCK AND MORPHOGEN GRADIENT REGULATE THE SOMITOGENESIS IN VERTEBRATES

The segmentation of the vertebrate body is established by somitogenesis, during which somite form sequentially in a rhythmic fashion from the paraxial presomitic mesoderm. The somites are transient embryonic segments giving rise to the vertebras, the skeletal muscles and dorsal epidermis. In vertebrates, all cells of the paraxial mesoderm go successively through the three phases of differentiation and matura- tion, which are tightly regulated at the spatio-temporal level.

Tail bud in the development of vertebrate embryos

In vertebrates, after the completion of gastrulation the rear end of the embryo, called the tail bud, is the mass of undifferentiated mesenchymal cells, which make up the lumbar and caudal sections of the body. Mesenchymal cells have the potency to differentiate into a variety of tissues, including neural tube secondary, small tail, somites and their derivatives. Describes some of the molecular mechanisms associated with the tail bud różnicowaniwm and discusses the role of the tail bud as the organizer of the rear part of the body of a vertebrate animal.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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