Current ideas concerning various aspects of the biology of dendritic cells (DC) were presented, including subdivision on two subsets and follow-ups of their activation. The issue of DC cross-presenta- tion (cross-priming) was discussed in detail as an important facet of their immunobiological function. The relevant role of DC in immunoregulation was underlined, particularly the action of immunosuppressive cytokines such as IL-10 and TGF-β and the enzyme indoleamine 2,3-dioxygenase (IDO). Attention was paid to the significance of DC in the induction of immunological tolerance.

Role of Toll-like receptors in immunity

Toll receptors belong to the family of receptors with a high evolutionary conservatism . They play an important role in the activation of insect resistance until wrodzonejod birds. For the first time been detected and characterized in Drosophila ( Drosophila melanogaster ) , where they are involved in embryogenesis and immunity against pathogens . We detected a homologous receptors in a mammal, including a human, which is called Toll -like receptors ( TLRs , Toll -Like Receptors ) .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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