Regulatory proteins SOCS 1-7 (suppressors of cytokine signaling), CIS (cytokine-inducible SH 2 protein) and other intracellular molecules such as JAKs (Janus tyrosine kinases), STATs family (signal transducers and activators of transcription), which participate in immunological response, could influence differentiation and proliferation, cell apoptosis, cell-cycle progression, cytokines and growth factors secretion by regulation of proper genes which determine these process in neoplasm cells and blood cells.

Toll-like receptors (TLRs), TNF receptor (TNF-R), NF-κB and the nuclear factor NF-κB family could influence cell-cycle progression, cell apoptosis, cytokines and adhesion molecules by regu- lation of proper genes which determine these process in neoplasm cells and blood cells. The aim of this study was to introduce the latest knowledge of the nuclear factor NF-κB family role in oncogenesis and neoplasm progression.