Role of stat proteins in inflammatory bowel diseases and colon carcinogenesis

STAT mediators comprise a family of seven proteins, that play a key role in intracellular signaling. They are involved in cell differentiation, proliferation and cell death. This article presents a description of STAT proteins with a focus on their probable role in pathology of alimentary system, particularly inflammatory bowel disease and colon carcinogenesis. In inflammatory bowel disease action of STAT3, STAT1, STAT 4 predominates. STAT1 and STAT3 play remarkable roles in colon carcinoma. It was discovered that STAT1 blocks cell proliferation in cell lines of colorectal cancer.

Human papillomavirus and the process of apoptosis

The importance of the effect of infection with human papilloma virus (HPV) , and the processes of carcinogenesis, apoptosis has been the subject of many studies , but is still little understood. The study aims to present the current knowledge of the impact of HPV infection on selected aspects of the processes of life and death of cells. Apoptosis is a complex process which leads to cell death , wherein the protein plays an important role of BCL - 2 family , as well as the cell cycle regulatory proteins include P53 and pRB .

Connections gap and their involvement in apoptosis and carcinogenesis

GAP junctions multicellular organisms are a necessary support member homeostatic control of growth and differentiation of cells. The existence of such a route of communication between the cells remaining in close contact is a prerequisite for the proper functioning of the body. Communication impairment (loss of connection gap) between the cells violates the homeostasis of these cells. The characteristics of cancer cells are abnormal for the control of growth and / or differentiation of these cells.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

PBK Postępby biologi komórki