FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

This paper presents current views on the basic stages in the development of coronary vessels in experimental animals. Tissue material for forming the coronary arteries provides temporary structure - przednasierdziowy organ that forms in the form of cell aggregates on the surface of the transverse ( in mammals ) or sinus venosus ( in birds ) . This organ is a direct precursor to the epicardium . The first buds of blood in the form of scattered islands of hematopoietic and vascular buds are formed in situ in the epicardium at the site of the sinus venosus and furrows: the coronary and forming a cavity formed between the aorta and pulmonary trunk arterial trunk . The germs are then channeled , and in an unknown way merge to form a continuous vascular system . The proximal portions of the coronary arteries arise from vascular buds , which are located around the trunk of the blood , the tabs that give the aortic sinuses , and form a connection to the light, forming a vascular passage way . At the same time leads to the formation of patent venous connection of the right atrium and the coronary sinus . After the blood flow in the coronary system channeled include signal for cell precursors differentiate into smooth muscle vessels. Diversification as a result of the acquisition by these cells of contractile phenotype antigens lasts until the end of fetal life . Growth factors involved in vascular angiogenesis , such as VEGF and angiopoietin ( -1 , -2) is expressed in fetal heart , and co-localization of sites of vessel formation . Coronary artery endothelial cells are derived from fetal liver region , adjacent to the forming przednasierdziowego organ , from reaching through the heart as angioblasty mesentery (or their precursors ) . Cells smooth muscle of blood and adventitia fibroblasts arise from epicardial mesothelium cells that as a result of epithelial-mesenchymal transformation they migrate to the respective myocardial and give rise to the appropriate cell lines ( miocytom smooth and fibroblasts ) .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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