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Leptin ? obesity gene product was discovered in 1994. It is synthesized predominantly in the white adipose tissue , but also in the ovary , placenta and mammary gland during lactation. Therefore , it is believed that leptin is involved in fetal and neonatal development . The main target of the leptin regulation of energy balance and reproductive function are the nucleus of the hypothalamus , which modifies the activity of the hypothalamic- pituitary . In genetically obese and infertile mice ( ob / ob) exogenous leptin restores fertility in both females and males. In adult rats , leptin stimulates both gonadotropin release (LHRH ) from the hypothalamus , as well as luteinizing hormone (LH) from the pituitary . More pronounced stimulating effect of leptin on the reproductive discloses obtaining during puberty and when the amount of energy supplied to the body is inadequate and the release of LH is inhibited and dopęcherzykowego hormone (FSH ) from the pituitary . In addition to the action of the hypothalamic - pituitary system , leptin also directly affects the ovarian function . However, the physiological and pathophysiological effects of leptin in the reproductive tract in both animals and humans should be further clarified .

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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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