FIND ARTICLE

Volume: 
Supplement: 
21
Date of issue: 

The primary disadvantage of cord blood as a source of cells for transplantation , the number of cells is small , usually less than 1 billion times, allowing operation only in children under 30 kg , while the majority of recipients has a larger weight. Hence the idea of simultaneous use of several units of cord blood , which together are designed to provide a sufficient number of cells for transplantation to an adult recipient. The bottom line is that the immune cells in cord blood , as young cells should not be able to cross- reactions against each other. Such reactions are the biggest threat to the success of the idea and therefore first tested whether co-culture of hematopoietic cells from two different cord blood units associated with their interaction affecting the number of generated hematopoietic colonies . Such tests revealed no differences in terms of mean values ​​, results were also observed but the opposite , i.e. both inhibition and stimulation in different combinations. We performed a clinical trial in an adult male with acute myeloid leukemia without remission , which przeszczepiliśmy cells with two different units of umbilical cord blood . We obtained documented implanting one of these two units and normalization of neutrophils . Overall , these results suggest that the test method of therapeutic promise for the future routine use in recipients who do not have either Kindred or unrelated donor bone marrow.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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