The article discusses the current views on the nature of centromeric chromatin formation neocentromerów for example; now it seems that no DNA but centromeric proteins determine the formation of neocentromerów. Building complexes centromere / kinetochore chromosomes holocentrycznych is similar to the chromosomes monocentrycznych. Centromeric DNA undergoes rapid divergence caused by point mutations and insertions and deletions. Centromere and kinetochore proteins - CENP - are conservative, ie, exhibit a significant degree of homology between yeast and higher eukaryotes - animals and plants. Deficiency, lack of or modifications to CENP cause failures of the centromere / kinetochore, expressing the incorrect segregation of sister chromatids in anafazie.Również conservative cohesion complex proteins.