FIND ARTICLE

METALLOPROTEINASE 9 (MMP-9) AS A UNIQUE MEMBER OF THE MATRIX METALLOPROTEINASE FAMILY: ROLE IN INFLUX OF NEUTROPHILS AND THEIR APOPTOSIS DURING INFLAMMATION

Matrix metalloproteinase (MMP) family consists of Zn2+-dependent endopeptidases. The enzymes degrade structural proteins of basement membranes and extracellular matrix facilitating tissue remodeling and cell mobility thus phenomena accompanying physiological and inflammatory processes as well as cancer diseases. One of the subgroups among MMPs is a subfamily of gelatinases consisting of gelatinase A (MMP-2) and gelatinase B (MMP-9).

Cyclooxygenase II. Nonsteroidal antiinflammatory drugs as inhibitors of

Discovered in 1897, aspirin (acetylsalicylic acid) was the most important and most widely used anti-inflammatory drug , analgesic and przeciwgoršczkowym in the twentieth century. Aspirin and its analogues called a common nonsteroidal antiinflammatory drugs ( NSAIDs) through a common mechanism działajš based on the ability to inhibit the enzyme cyclooxygenase . Cyclooxygenase istniejš in at least two varieties: constitutive (COX -1) and inducible (COX -2). Aspirin and other NSAIDs inhibit both isoforms invol COX .

I. The role of cyclooxygenase in inflammatory reaction

Katalizujšcymi are enzymes cyclooxygenase metabolism of phospholipids of the cell membrane to the formation of prostanoids ties conducting obejmujšcych prostaglandin and thromboxanes . Prostaglandin kontrolujš variety of physiological processes , such as protection of the gastrointestinal tract, the proper functioning of the kidneys, reproductive processes , and the course of inflammation . It is now known that cyclooxygenase (COX ) is present in at least two isoforms encoded by genes located on different chromosomes .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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