Stress and the internal replication checkpoint S phase

Many research programs focused on understanding the mechanism of action of the internal S -phase checkpoint , which oversees both the processes associated with the frequency of initiation of DNA replication (density regions of origin ) and with the replication fork movement ( elongation rate ) . Replication rate decreases in response to hydroxyurea , aphidicolin or DNA damaging agents .

Mechanisms of chromosome condensation

Mitotic chromosome condensation and segregation are two processes that ensure proper inheritance replicated genome sequence . Although since the publication of the Walther Fleming and published in the first drawings of mitotic cells salamanders have passed more than 120 years , the current state of knowledge still does not allow for the creation of a universal model describing the formation and separation of sister chromatids .

Cellular regulatory systems. Feedback mechanisms and substrate-product relationship in the cell cycle

The correct sequence of events in the cell cycle progression is monitored by a complex molecular mechanism , wherein the anchor points serve as signal transduction pathways , both operated upon detection of disturbances in the assembly of cellular structures , and in the normal course of subsequent stages of interphase and mitosis. The system of these points in time starts and stops the key enzymes controlling the cell cycle , and any signals of structural disruption or damage following reactions converts blocking DNA synthesis or by inhibiting the initiation of cell division.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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