Mitotic chromosome condensation and segregation are two processes that ensure proper inheritance replicated genome sequence . Although since the publication of the Walther Fleming and published in the first drawings of mitotic cells salamanders have passed more than 120 years , the current state of knowledge still does not allow for the creation of a universal model describing the formation and separation of sister chromatids . Molecular studies indicate that these structures organize involving at least three categories of proteins: ( 1 ) forming the basic components of the interphase chromatin form - core histones and histone H1, ( 2 ) a molecule associated with chromatin in the course of cell cycle , but having different functions in the subsequent stages , such as topoisomerase II , and (3 ) and condensin cohesin complexes , the names of which indicate the involvement of the fusion processes and chromosome condensation . All of these proteins , together with other , not yet known factors involved in the process of forming mitotic chromatin form without changing the basic molecular components present in the interphase nuclei .