FIND ARTICLE

Volume: 
Supplement: 
21
Date of issue: 

Neurodegenerative diseases are a heterogeneous group of diseases with different clinical pictures and different medium , whose common feature is the dysfunction or loss of particularly vulnerable populations of nerve cells. The presence of a selective loss of nerve cells allows the use of a single therapeutic strategy is to replace losses of new cells , able to take the functions of lost cells. For 20 years now attempt to restore normal function via neural stem cell transplantation in neurodegenerative diseases , in particular Parkinson's disease and Huntington's . The clinical trials have so far focused on the transplantation of fetal neural tissue fragments , containing a partially differentiated dopaminergic neuroblasts which the host brain are capable of differentiating into mature neurons . The recent discovery that the immature , multipotent , neural progenitor cells can be isolated from the central nervous system , both the developing embryo and mature organism and maintained and amplified in culture , provides additional opportunities for potential applications in neuronal loss and replacement gene therapy. The presence of the bone marrow and umbilical cord blood stem / progenitor cells that have the ability to self-replication and differentiation in vitro nerve cells nieembrionalnych opens the possibility of using stem cells from these sources in the treatment of neurodegenerative diseases and brain injury . The objective of this study is a critical analysis of the available literature examples acquisition and use of stem / progenitor cells in the treatment of neurological disorders and reflection on key issues that must be solved in order to stem cells have become a useful therapeutic tool .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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