The fat tissue is very dynamic , and as a result of hyperplasia , which is a consequence of the proliferation and differentiation of preadipocytes may contribute to the development of obesity. This process is regulated by a complex number of specific genes. Among them, certainly deserves attention PPARg receptor whose expression is noted particularly strong in adipose tissue . It is a key factor in the adipogenesis process and is responsible for the differentiation of preadipocytes into mature cells called adipocytes . In addition , it regulates lipid metabolism in adipose tissue .

The aim of the presented paper is the description of disturbances in the central nervous system (OUN) functions of fa/fa Zucker rats, in which the development of morbid obesity is observed as a result of a defect in leptin functioning. Zucker fa/fa rats possess a defect in a gene, which codes leptin receptor. A single exchange of adenine to cytosine in the 806th position of extracellular domain of the receptor results in coding proline instead of glutamine (Gln269Pro).

The share of opioids in the local regulation of ovarian function

The article presents the results of their research on the secretion of immunoreactive b-endorphin in vitro by anterior pituitary cells, and various types of pig ovary cells: luteal, granulosa and theca). Also described is a local role in the regulation of the opioid of LH secretion by the pituitary and ovarian steroid hormones in pigs.