Mesenchymal stem cells (MSC) are considered to be a promising tool for cellular transplantations. This population of cells can find potential applications in multiple clinical disorders as a stimulant for regeneration and/or an immuno-modulator for the treated tissue. As adult stem cells, MSC allow performance of autologous transplantations. Therefore, it is crucial to understand the relationships between ageing and properties of this cell population.

Ageing and diseases connected with ageing currently became very important social problem. Ageing processes can be faster because of accumulation of toxic metabolic products. This substances could be products of non enzymatic glycosylation (glycation). Glycation may there fore play an impor- tant role in ageing and has been implicated in the pathophysiology of a number of diseases, like: Alzheimer disease, arteriosclerosis, diabetes, kidney diseases, blood circulation system diseases and lung diseases.

Increasing rate of aged people in societies of developed countries is inevitably connected with occurrence of health problems closely related to this period of life. Ageing as well as old age itself, being a stage of life, are associated with coexisting involutional changes in organs, systems of organs, and old age diseases, accompanying this period of life. In physiological ageing process the disorders mainly concern haematopoesis, especially in conditions of so called hematological stress.